Jaishree T N, Wang A H
Biophysics Division, University of Illinois at Urbana-Champaign 61801.
FEBS Lett. 1994 Jun 20;347(1):99-103. doi: 10.1016/0014-5793(94)00516-8.
Nine DNA sequences related to the purine strand of the human centromeric satellite (AATGG)n (CCATT)n repeat have been studied by two-dimensional nuclear magnetic resonance spectroscopy. Earlier studies have suggested that the structure of (AATGG)n sequence has an equilibrium between the duplex form and a fold-back form. Structural refinement of d(CAATGG) and its related sequences by an NOE-constrained simulated annealing procedure reveals that the duplex form incorporates dynamic type-I G-A base pairs. 1D exchangeable proton NMR data support this model. The reverse sequence motif (GGTAA) destabilizes the structure.
