Ali K Z, Dickson G R
Department of Anatomy, College of Medicine, King Saud University, Saudi Arabia.
J Anat. 1994 Apr;184 ( Pt 2)(Pt 2):347-53.
To investigate the effect of the fibula on growth of the tibia in the rat, (1) a sleeve of periosteum was removed from the middle third of the tibia, (2) a length of the fibula was excised, or (3) a sleeve of periosteum was removed from the middle third of the tibia and a length of fibula was also excised. Over a 14 wk experimental period subsequent tibial bone growth was measured on radiographs and compared with unoperated contralateral control tibiae. Procedure (1) had no effect on growth, (2) resulted in 4.2% overgrowth and (3) produced 19.7% overgrowth compared with control tibiae. The failure of overgrowth after periosteal resection from the middle third of the rat tibia argues against the vascular response theory in relation to bone overgrowth. The longitudinal overgrowth after procedure (2) and its further accentuation by procedure (3) suggests that the fibula influences tibial bone growth by exerting a mechanical restraint on it, which is reciprocal to the restraining influence of the tibial periosteum. Overgrowth appears to be facilitated by decompression of the cartilage growth plate of the rat tibia when a sleeve of the periosteum is removed from it, and this suggests a mechanical relationship between the fibrous periosteum and the cartilage growth plate of the tibia. It is concluded that the fibula plays a reciprocal role in regulating tibial bone growth in the rat.
为研究腓骨对大鼠胫骨生长的影响，进行了以下操作：（1）从胫骨中三分之一处去除一层骨膜；（2）切除一段腓骨；或（3）从胫骨中三分之一处去除一层骨膜并切除一段腓骨。在为期14周的实验期内，通过X线片测量后续胫骨的生长情况，并与未手术的对侧对照胫骨进行比较。操作（1）对生长无影响，操作（2）导致胫骨生长超出4.2%，操作（3）导致胫骨生长超出19.7%。从大鼠胫骨中三分之一处切除骨膜后未出现生长过度，这与骨生长过度的血管反应理论相悖。操作（2）后出现的纵向生长过度以及操作（3）使其进一步加剧，表明腓骨通过对胫骨施加机械性限制来影响胫骨生长，这与胫骨骨膜的限制作用相互对应。当从大鼠胫骨去除一层骨膜时，胫骨软骨生长板减压似乎促进了生长过度，这表明纤维性骨膜与胫骨软骨生长板之间存在机械关系。得出结论，腓骨在调节大鼠胫骨生长中起相互作用的作用。
