大鼠胫骨生长板对远端骨膜分割的反应。
The response of the rat tibial growth plates to distal periosteal division.
作者信息
Taylor J F, Warrell E, Evans R A
机构信息
Department of Orthopaedics, Liverpool University.
出版信息
J Anat. 1987 Apr;151:221-31.
The growth plate chondrocytes have been examined in the tibiae of normal immature rats and in similar rats after circumferential distal periosteal release. In control rats, calculation of the growth rate as the product of the rate of cell proliferation and the maximum hypertrophic cell height correlated with gross measurements. The labelling index also correlated with the calculated growth rate. During the period 28 to 46 days of age there was little change in the growth rate but a diminution in the height of the hypertrophic cells. Unilateral circumferential periosteal division produced bilateral increases in tibial growth rate and in the activity of both the proliferative and hypertrophic zones as part of the systemic response to the trauma. There was a 1% ipsilateral increase in tibial length, as compared to the contralateral side, which appeared to be related principally to an increase in the number of proliferative cells. This simple method of stimulating bone growth can usefully be undertaken at the same time as other operative procedures.
在正常未成熟大鼠的胫骨以及在进行远端周向骨膜松解后的类似大鼠的胫骨中，对生长板软骨细胞进行了检查。在对照大鼠中，将生长速率计算为细胞增殖速率与最大肥大细胞高度的乘积，这与大体测量结果相关。标记指数也与计算出的生长速率相关。在28至46日龄期间，生长速率变化不大，但肥大细胞高度减小。单侧周向骨膜切开术导致胫骨生长速率以及增殖区和肥大区的活性出现双侧增加，这是对创伤的全身反应的一部分。与对侧相比，胫骨长度同侧增加了1%，这似乎主要与增殖细胞数量的增加有关。这种刺激骨生长的简单方法可以与其他手术操作同时有效地进行。
Zotero 插件