Lovrich S D, Callister S M, Lim L C, DuChateau B K, Schell R F
Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison.
J Infect Dis. 1994 Jul;170(1):115-21. doi: 10.1093/infdis/170.1.115.
Five distinct seroprotective groups among North American and European isolates of Borrelia burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii have been identified using the in vitro borreliacidal assay. The predominant North American seroprotective group comprised isolate 297 and B. burgdorferi isolates from California, Illinois, Wisconsin, New York, and Texas. A second group was represented by isolate C-1-11. The majority of European isolates belonged to a seroprotective group composed of B. garinii. Another European group contained isolates classified genetically as genospecies group VS461 (B. afzelii). A fifth group, represented by isolate LV5, could kill both North American and European isolates of B. burgdorferi sensu lato. These results suggest that combinations of immunogenic protective proteins of spirochetes will be necessary to provide a comprehensive vaccine.
利用体外杀螺旋体试验，已在北美和欧洲的狭义伯氏疏螺旋体、伽氏疏螺旋体和阿氏疏螺旋体分离株中鉴定出五个不同的血清保护组。北美主要的血清保护组包括分离株297以及来自加利福尼亚州、伊利诺伊州、威斯康星州、纽约州和得克萨斯州的伯氏疏螺旋体分离株。第二组以分离株C-1-11为代表。大多数欧洲分离株属于由伽氏疏螺旋体组成的血清保护组。另一个欧洲组包含在基因上分类为基因种VS461组（阿氏疏螺旋体）的分离株。以分离株LV5为代表的第五组能够杀死北美和欧洲的广义伯氏疏螺旋体分离株。这些结果表明，螺旋体免疫原性保护蛋白的组合对于提供一种全面的疫苗将是必要的。
