Spooner B S, Hardman P, Paulsen A
Division of Biology, Kansas State University, Manhattan 66506-4901.
J Exp Zool. 1994 Jul 1;269(3):212-22. doi: 10.1002/jez.1402690306.
Organ culture of embryonic mouse lung and pancreas rudiments has been used to investigate development and differentiation, and to assess the effects of microgravity on culture differentiation, during orbital spaceflight of the shuttle Endeavour (mission STS-54). Lung rudiments continue to grow and branch during spaceflight, an initial result that should allow future detailed study of lung morphogenesis in microgravity. Cultured embryonic pancreas undergoes characteristic exocrine acinar tissue and endocrine islet tissue differentiation during spaceflight, and in ground controls. The rudiments developing in the microgravity environment of spaceflight appear to grow larger than their ground counterparts, and they may have differentiated more rapidly than controls, as judged by exocrine zymogen granule presence.
胚胎小鼠肺和胰腺原基的器官培养已被用于研究发育和分化，并在奋进号航天飞机（STS - 54任务）的轨道太空飞行期间评估微重力对培养物分化的影响。在太空飞行过程中，肺原基持续生长并分支，这一初步结果应能使未来对微重力环境下的肺形态发生进行详细研究。培养的胚胎胰腺在太空飞行期间以及在地面对照实验中都会经历典型的外分泌腺泡组织和内分泌胰岛组织分化。在太空飞行的微重力环境中发育的原基似乎比在地面上的对应物长得更大，并且从外分泌酶原颗粒的存在情况判断，它们的分化速度可能比对照组更快。
