Barron B J, Robinson L, Tran H D, Lamki L
Department of Radiology, University of Texas Health Science Center at Houston.
J Nucl Med. 1994 Jul;35(7):1167-9.
Sternal abnormalities in sickle-cell disease have been documented by bone scintigraphy and radiography in patients with homozygous sickle-cell anemia, but not in patients with sickle-thalassemia. We present here two unusual cases of sternal abnormalities in complicated sickle-cell disease. One is an infant with radiographic findings of "sternal cupping" and transient hypo-ossification of the sternum and sickle-thalassemia. The other patient is also a male infant with unusual, persistent under-ossification of bone, in association with radiographic findings of "sternal cupping." The second patient also had a 4P-chromosomal defect (Wolf-Hirschhorn syndrome) in which sternal hypo-ossification was described.
骨闪烁显像和X线摄影已记录到纯合子型镰状细胞贫血患者存在镰状细胞病的胸骨异常，但镰状细胞-地中海贫血患者未出现此类情况。我们在此报告两例复杂镰状细胞病伴胸骨异常的罕见病例。一例是一名婴儿，X线摄影显示有“胸骨杯状畸形”以及胸骨短暂性骨化不足，诊断为镰状细胞-地中海贫血。另一例患者也是一名男婴，伴有异常的、持续性骨化不足，并伴有“胸骨杯状畸形”的X线摄影表现。第二名患者还患有4号染色体缺陷（沃尔夫-赫希霍恩综合征），其中也描述了胸骨骨化不足的情况。
