Christensen R D, Hunter D D, Ohls R K
Clinical Research Center, University of Utah School of Medicine, Salt Lake City 84132.
J Perinatol. 1994 Mar-Apr;14(2):110-3.
Sixteen infants with the anemia of prematurity were randomly assigned to treatment with packed erythrocyte transfusions, recombinant erythropoietin alone, or epo plus recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF). During the treatment period, blood reticulocyte concentrations remained unchanged in those randomly assigned to receive transfusions, but increased significantly in those who received erythropoietin, either alone or in combination with GM-CSF. The magnitude of increase in hematocrit was not greater in those who received erythropoietin plus GM-CSF than in those who received erythropoietin alone. Blood neutrophil concentrations fell in all four infants who received erythropoietin alone, but increased in all who received erythropoietin plus GM-CSF.
16名早产贫血婴儿被随机分配接受浓缩红细胞输血治疗、单独使用重组促红细胞生成素治疗或促红细胞生成素加重组粒细胞巨噬细胞集落刺激因子（GM-CSF）治疗。在治疗期间，随机分配接受输血的婴儿的血液网织红细胞浓度保持不变，但接受促红细胞生成素单独治疗或与GM-CSF联合治疗的婴儿的血液网织红细胞浓度显著增加。接受促红细胞生成素加GM-CSF治疗的婴儿的血细胞比容增加幅度并不大于接受促红细胞生成素单独治疗的婴儿。单独接受促红细胞生成素治疗的4名婴儿的血液中性粒细胞浓度下降，但接受促红细胞生成素加GM-CSF治疗的所有婴儿的血液中性粒细胞浓度均升高。
