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本文引用的文献

1
The role of recombinant Human erythropoietin in neonatal anemia.重组人促红细胞生成素在新生儿贫血中的作用。
Hematol Oncol Stem Cell Ther. 2020 Sep;13(3):147-151. doi: 10.1016/j.hemonc.2019.08.004. Epub 2019 Oct 11.
2
Darbepoetin administration to neonates undergoing cooling for encephalopathy: a safety and pharmacokinetic trial.对因脑病接受降温治疗的新生儿给予达比泊汀：一项安全性和药代动力学试验。
Pediatr Res. 2015 Sep;78(3):315-22. doi: 10.1038/pr.2015.101. Epub 2015 May 21.
3
A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants.达贝泊汀α治疗早产儿的随机、盲法、安慰剂对照研究。
Pediatrics. 2013 Jul;132(1):e119-27. doi: 10.1542/peds.2013-0143. Epub 2013 Jun 17.
4
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?新生儿中性粒细胞减少症：需要进行哪些诊断评估，何时推荐治疗？
Early Hum Dev. 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5.
5
Anaemia of prematurity: pathophysiology and treatment.早产儿贫血：病理生理学与治疗。
Blood Rev. 2010 Nov;24(6):221-5. doi: 10.1016/j.blre.2010.08.001.
6
Anemia in the preterm infant: erythropoietin versus erythrocyte transfusion--it's not that simple.早产儿贫血：促红细胞生成素与红细胞输血——并非如此简单。
Clin Perinatol. 2009 Mar;36(1):111-23. doi: 10.1016/j.clp.2008.09.009.
7
PLASMA ERYTHROPOIETIN LEVELS IN CORD BLOOD AND IN BLOOD DURING THE FIRST WEEKS OF LIFE.出生时脐带血及出生后第一周血液中的血浆促红细胞生成素水平
Acta Paediatr (Stockh). 1963 Sep;52:425-35. doi: 10.1111/j.1651-2227.1963.tb03802.x.
8
Effects of early erythropoietin therapy on the transfusion requirements of preterm infants below 1250 grams birth weight: a multicenter, randomized, controlled trial.早期促红细胞生成素治疗对出生体重低于1250克的早产儿输血需求的影响：一项多中心、随机、对照试验。
Pediatrics. 2001 Oct;108(4):934-42. doi: 10.1542/peds.108.4.934.
9
Late-onset neutropenia in very low birth weight infants.极低出生体重儿迟发性中性粒细胞减少症
Pediatrics. 2000 Oct;106(4):E55. doi: 10.1542/peds.106.4.e55.
10
Erythropoietin to prevent and treat the anemia of prematurity.促红细胞生成素用于预防和治疗早产儿贫血。
Curr Opin Pediatr. 1999 Apr;11(2):108-14. doi: 10.1097/00008480-199904000-00002.

达贝泊汀α给药后早产儿中性粒细胞减少症的特征

Characterization of Neutropenia in Preterm Neonates Following Administration of Darbepoetin Alfa.

作者信息

Andrews Nicole, Friedman Stephanie, Dunham Mary, Dean Roger, Chabra Shilpi

机构信息

Department of Pharmacy (NA), Harborview Medical Center, Seattle, WA.

Department of Pharmacy (NA, SF, MD, RD), University of Washington Medical Center, Seattle, WA.

出版信息

J Pediatr Pharmacol Ther. 2023;28(1):41-47. doi: 10.5863/1551-6776-28.1.41. Epub 2023 Feb 3.

DOI:10.5863/1551-6776-28.1.41
PMID:36777988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9901317/
Abstract

OBJECTIVE

This study is to evaluate the effects of darbepoetin alfa (darbe) on neutrophil count in preterm neonates treated for anemia of prematurity.

METHODS

This was a retrospective chart review comparing the absolute neutrophil counts (ANCs) of neonates administered 2 doses of subcutaneous darbe 10 mcg/kg to that of a randomly selected comparator group of neonates not administered the drug. Neonates <34 weeks gestational age, gestational age between 23w1d and 33w4d, born between July 2016 and June 2019, were included in the study.

RESULTS

The ANCs of 45 darbe-treated neonates compared with those of 45 randomly selected comparator control neonates revealed no difference in the rate of occurrence of neutropenia (ANC ≤1000/μL) between the darbe-treated neonates (26.7%) and comparator neonates (24.4%) (p > 0.99). There was also no difference in the rate of occurrence of severe neutropenia (ANC ≤500/μL) between the darbe-treated neonates (11.1%) and comparator neonates (6.7%) (p = 0.70). Darbepoetin alfa did not lead to differences in rates of resolution of neutropenia or severe neutropenia.

CONCLUSIONS

Short-term administration of darbe did not affect the ANCs of preterm neonates treated for anemia of prematurity. There was no difference in the rates of occurrence of neutropenia, severe neutropenia, or resolution of either between the darbe-treated neonates and comparator neonates.

摘要

目的

本研究旨在评估阿法达贝泊汀（darbe）对接受治疗的早产新生儿中性粒细胞计数的影响。

方法

这是一项回顾性图表审查，比较了皮下注射两剂10 mcg/kg阿法达贝泊汀的新生儿与随机选择的未给药对照组新生儿的绝对中性粒细胞计数（ANC）。纳入研究的新生儿孕周<34周，孕周在23周1天至33周4天之间，于2016年7月至2019年6月出生。

结果

45例接受阿法达贝泊汀治疗的新生儿与45例随机选择的对照新生儿的ANC比较显示，阿法达贝泊汀治疗组新生儿（26.7%）和对照组新生儿（24.4%）的中性粒细胞减少症（ANC≤1000/μL）发生率无差异（p>0.99）。阿法达贝泊汀治疗组新生儿（11.1%）和对照组新生儿（6.7%）的严重中性粒细胞减少症（ANC≤500/μL）发生率也无差异（p=0.70）。阿法达贝泊汀未导致中性粒细胞减少症或严重中性粒细胞减少症的缓解率出现差异。

结论

短期使用阿法达贝泊汀不影响接受治疗的早产新生儿的ANC。阿法达贝泊汀治疗组新生儿和对照组新生儿在中性粒细胞减少症、严重中性粒细胞减少症的发生率或两者的缓解率方面均无差异。