Kiho T, Tsujimura Y, Sakushima M, Usui S, Ukai S
Gifu Pharmaceutical University, Japan.
Yakugaku Zasshi. 1994 May;114(5):308-15. doi: 10.1248/yakushi1947.114.5_308.
Glucuronoxylomannan (AC) from the fruiting bodies of Tremella fuciformis exhibited a significant dose-dependent hypoglycemic activity in normal mice and also showed a significant activity in streptozotocin-induced diabetic mice, by intraperitoneal (i.p.) administration. The activities of AC-derivatives such as a product of AC which side chains had been removed were lower than that of native AC. AC raised the plasma insulin level in normal mice. Administration of AC to normal mice significantly increased the activities of hepatic hexokinase and glucose-6-phosphatase dehydrogenase, but it decreased that of hepatic glucose-6-phosphatase. Furthermore, AC reduced the glycogen content in the liver, increased the total lipid in epididymal adipose tissue, and lowered the plasma cholesterol level. The foregoing results indicated that the hypoglycemic activity of AC in normal mice was at least responsible for the increase of insulin secretion and for the acceleration of glucose metabolism. Single oral administration at a dose of 50-300 mg/kg of AC did not affect the plasma glucose level in normal mice, but continuous oral administrations of the AC solution (0.75 g/l) instead of water for a long time was found to be effective on the plasma glucose level in both experiments of the mice injected once i.p. with streptozotocin (170 mg/kg) at 0 d of AC administration and streptozotocin-induced diabetic mice.
从银耳子实体中提取的葡糖醛酸木聚糖甘露聚糖（AC）经腹腔注射给药后，在正常小鼠中表现出显著的剂量依赖性降血糖活性，在链脲佐菌素诱导的糖尿病小鼠中也显示出显著活性。AC的衍生物（如侧链已去除的AC产物）的活性低于天然AC。AC可提高正常小鼠的血浆胰岛素水平。给正常小鼠施用AC可显著提高肝脏己糖激酶和葡萄糖-6-磷酸脱氢酶的活性，但会降低肝脏葡萄糖-6-磷酸酶的活性。此外，AC可降低肝脏中的糖原含量，增加附睾脂肪组织中的总脂质，并降低血浆胆固醇水平。上述结果表明，AC在正常小鼠中的降血糖活性至少与胰岛素分泌增加和葡萄糖代谢加速有关。以50-300mg/kg的剂量单次口服AC对正常小鼠的血浆葡萄糖水平没有影响，但在AC给药第0天腹腔注射一次链脲佐菌素（170mg/kg）的小鼠实验和链脲佐菌素诱导的糖尿病小鼠实验中，长期连续口服AC溶液（0.75g/l）代替水被发现对血浆葡萄糖水平有效。
