Taneda M, Satoh H, Nakamura K, Tsutsumi T, Saruki N, Katoh K, Araki Y
Department of Anesthesiology, Japanese Red Cross Medical Center, Tokyo.
Masui. 1994 May;43(5):717-21.
We evaluated the effects of pirenzepine on salivary secretion and heart rate, comparing them with those after atropine. Forty-two patients for gynecological operations were divided into three groups. P, A and C groups received pirenzepine 10 mg, atropine 0.5 mg and saline 1 ml intravenously 4 min before induction. Salivary secretion was aspirated at 30, 60 and 120 min after induction. Heart rate was recorded at 1, 30, 60 and 120 min after injection. In P and A groups, salivary secretion decreased significantly, but there was no significant difference between them. In A group, heart rate increased at 1, 30 and 60 min after injection, but at 120 min there was no difference among three groups. We conclude that intravenous pirenzepine as well as atropine reduces salivary secretion, but it does not increase heart rate as atropine.
我们评估了哌仑西平对唾液分泌和心率的影响，并将其与阿托品后的影响进行比较。42例妇科手术患者分为三组。P、A和C组在诱导前4分钟静脉注射10毫克哌仑西平、0.5毫克阿托品和1毫升生理盐水。诱导后30、60和120分钟抽吸唾液分泌。注射后1、30、60和120分钟记录心率。在P组和A组中，唾液分泌显著减少，但两组之间无显著差异。在A组中，注射后1、30和60分钟心率增加，但在120分钟时三组之间无差异。我们得出结论，静脉注射哌仑西平与阿托品一样可减少唾液分泌，但它不会像阿托品那样增加心率。
