骨髓移植治疗儿童再生障碍性贫血或急性白血病。
Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia.
作者信息
Johnson F L, Hartmann J R, Thomas E D, Chard R L, Hersman J A, Buckner C D, Clift R A, Storb R
出版信息
Arch Dis Child. 1976 Jun;51(6):403-10. doi: 10.1136/adc.51.6.403.
Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 33 patients (24%) receiving allogeneic and 5 of 8 (63%) receiving syngeneic transplantations are continuing in remission from 3 months to beyond 2 years. The longest continuing remission off therapy is now over 4 1/2 years after preparation with total body irradiation. The major causes of failure remain graft-versus-host disease, infection, graft rejection (aplastic anaemia), and leukaemic relapse.
76名年龄在2至17岁之间的患者因严重再生障碍性贫血或对传统疗法难治的急性白血病接受了骨髓移植治疗。在22名接受再生障碍性贫血骨髓移植的患者中，有16名（73%）存活，其中12名存活超过一年。在急性白血病中，采用环磷酰胺预处理和全身照射，33名接受异基因移植的患者中有8名（24%）、8名接受同基因移植的患者中有5名（63%）持续缓解3个月至2年以上。在全身照射预处理后，目前最长的持续缓解期已超过4年半。失败的主要原因仍然是移植物抗宿主病、感染、移植物排斥（再生障碍性贫血）和白血病复发。
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