Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia.
作者信息
Johnson F L, Hartmann J R, Thomas E D, Chard R L, Hersman J A, Buckner C D, Clift R A, Storb R
出版信息
Arch Dis Child. 1976 Jun;51(6):403-10. doi: 10.1136/adc.51.6.403.
Abstract
Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 33 patients (24%) receiving allogeneic and 5 of 8 (63%) receiving syngeneic transplantations are continuing in remission from 3 months to beyond 2 years. The longest continuing remission off therapy is now over 4 1/2 years after preparation with total body irradiation. The major causes of failure remain graft-versus-host disease, infection, graft rejection (aplastic anaemia), and leukaemic relapse.
摘要
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