含地西泮直肠栓剂的制剂及其生物药剂学研究经验
Formulation of diazepam containing rectal suppositories and experiences of their biopharmaceutical study.
作者信息
Regdon G, Bácskay I, Kata M, Selmeczi B, Szikszay M, Sánta A, Bálint G S
机构信息
Albert Szent-Györgyi Medical University, Department of Pharmaceutical Technology, Szeged, Hungary.
出版信息
Pharmazie. 1994 May;49(5):346-9.
PMID:8016180
Abstract
Methodology and the results of the in vitro membrane diffusion and in vivo bioavailability studies are presented. The results confirm a correlation between in vitro and in vivo findings. Hydrophilic macrogol-mixture with great molecular mass can be recommended as the optimal vehicle for formulation of diazepam suppositories.
摘要
本文介绍了体外膜扩散和体内生物利用度研究的方法及结果。结果证实了体外和体内研究结果之间的相关性。高分子量亲水性聚乙二醇混合物可被推荐为制备地西泮栓剂的最佳载体。
Zotero 插件