Olofsson M J, Scheibel E, Clausen N, Pedersen F K, Peitersen B
Dansk Paediatrisk Selskabs AIDS-udvalg, København.
Ugeskr Laeger. 1994 Apr 25;156(17):2575-9.
The AIDS-committee of The Danish Society of Paediatrics has done a nation-wide study among infants and children under the age of 15 with AIDS or HIV-antibodies in preparation for planning prevention and treatment. Clinical data have been collected from the Departments of Paediatrics and Infectious Diseases, Haemophilia, Dermatology and Internal Medicine up to 1 March 1993. The study includes 44 infants with a risk of vertical transmission from the mother and 16 children with haemophilia. No cases were found to be infected by blood-transfusion. Twenty of the 44 infants with congenital HIV-antibodies were HIV-infected. Seven of them died from AIDS, 10 currently have AIDS and three are asymptomatic. Seventeen infants are well and HIV-antibody negative after the age of 18 months. Seven infants still have unclarified status, but all are well. Three of the patients with haemophilia are dead. The 13 others do not have AIDS. It is surprising that most of the infected infants' mothers were not known to be infected before the infants got sick. Thus infected infants exist in families who are not suspected to be HIV-infected. The AIDS-committee of The Danish Society of Paediatrics has proposed recommendations for HIV-testing of infants and children. HIV-infected families need comprehensive psychosocial care. The risk-factor from blood-transfusion is now eliminated, but vertical transmission will continue to be a risk-factor. The size of the problem in Denmark will not be known until an epidemiological study of pregnant women has been conducted.
丹麦儿科学会艾滋病委员会针对15岁以下感染艾滋病或携带艾滋病毒抗体的婴幼儿开展了一项全国性研究,为预防和治疗计划做准备。截至1993年3月1日,已从儿科、传染病科、血友病科、皮肤科和内科收集了临床数据。该研究包括44名有母婴垂直传播风险的婴儿和16名血友病患儿。未发现因输血感染的病例。44名先天性携带艾滋病毒抗体的婴儿中有20名感染了艾滋病毒。其中7名死于艾滋病,10名目前患有艾滋病,3名无症状。17名婴儿在18个月大后情况良好且艾滋病毒抗体呈阴性。7名婴儿的状况仍不明朗,但均情况良好。3名血友病患者已死亡。其他13名患者未患艾滋病。令人惊讶的是,大多数受感染婴儿的母亲在婴儿患病前并不知晓自己已被感染。因此,在未被怀疑感染艾滋病毒的家庭中也存在受感染的婴儿。丹麦儿科学会艾滋病委员会已就婴幼儿艾滋病毒检测提出了建议。艾滋病毒感染家庭需要全面的心理社会护理。输血带来的风险因素现已消除,但母婴垂直传播仍将是一个风险因素。在对孕妇进行流行病学研究之前,丹麦这一问题的严重程度尚不清楚。