Martínez Seeber A, Fernández B E, Domínguez A E, Vidal N A
Arch Int Physiol Biochim. 1978 Feb;86(1):175-8.
The effects of the infusion of Saralasin and SQ 20881, two drugs that inhibit the renin-angiotensin system, on the norepinephrine (NE) concentration in hypothalamus and medulla oblongata were studied in male Wistar rats. NE content increased in hypothalamus in response to both drugs, without changes in medulla oblongata catecholamine concentration. These results showed that the NE concentration of certain areas of the central nervous system can be modified, in a short time, by the inhibition of the renin-angiotensin system. Results observed after the infusion of Saralasin could indicate that the receptors, on which the angiotensin acts to produce this alteration, are similar to those of the peripheral blood vessels.
在雄性Wistar大鼠中，研究了两种抑制肾素-血管紧张素系统的药物沙拉新（Saralasin）和SQ 20881的输注对下丘脑和延髓中去甲肾上腺素（NE）浓度的影响。两种药物均可使下丘脑NE含量增加，而延髓儿茶酚胺浓度无变化。这些结果表明，抑制肾素-血管紧张素系统可在短时间内改变中枢神经系统某些区域的NE浓度。输注沙拉新后观察到的结果可能表明，血管紧张素作用产生这种改变的受体与外周血管的受体相似。
