诺卡氏菌组分对腹膜巨噬细胞的体外激活作用。
Activation in vitro of peritoneal macrophages by a nocardia fraction.
作者信息
Ben-Efraim S, Rashid G, Gittel H, Tax C, Ciorbaru R B
机构信息
Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Israel.
出版信息
Anticancer Res. 1994 Mar-Apr;14(2A):449-52.
The Nocardia fraction NLD-RB1040 (Nocardia Lysozyme Digest) induced cytostatic activity in vitro against the YAC-1 tumor-cell line, in resident murine peritoneal macrophages isolated from BALB/c mice. The induction of antitumor activity by the Nocardia fraction was not correlated with induced changes in production of TNF alpha, PGE2 or nitrite by human peritoneal macrophages collected from renal patients on Continuous Ambulatory Peritoneal Dialysis (CAPD), or changes in production of TNF a by murine macrophages.
诺卡氏菌组分NLD-RB1040（诺卡氏菌溶菌酶消化物）在体外对YAC-1肿瘤细胞系以及从BALB/c小鼠分离的常驻鼠腹膜巨噬细胞具有细胞抑制活性。诺卡氏菌组分诱导的抗肿瘤活性与持续性非卧床腹膜透析（CAPD）的肾病患者收集的人腹膜巨噬细胞中TNFα、PGE2或亚硝酸盐产生的诱导变化无关，也与鼠巨噬细胞中TNFα产生的变化无关。
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