Herrick A L, Oogarah P K, Freemont A J, Marcuson R, Haeney M, Jayson M I
Rheumatic Diseases Centre, University of Manchester, Hope Hospital, Salford, United Kingdom.
Ann Rheum Dis. 1994 May;53(5):323-6. doi: 10.1136/ard.53.5.323.
To document the incidence of histological vasculitis in amputation specimens from patients with severe digital ischaemia secondary to systemic sclerosis (SSc), and to look for an association between anticardiolipin (aCL) antibodies and severe digital ischaemia in SSc.
This was a retrospective review of patients with SSc who underwent amputation for digital ischaemia over a three year period.
Five of nine patients had histological vasculitis, four of whom had aCL antibodies, although these were not present in high titre.
Vasculitis does occur in SSc, at least in that subgroup with severe peripheral ischaemia. These findings could have implications for treatment of this subgroup of patients with SSc.
记录系统性硬化症（SSc）继发严重手指缺血患者截肢标本中组织学血管炎的发生率，并寻找抗心磷脂（aCL）抗体与SSc患者严重手指缺血之间的关联。
这是一项对在三年期间因手指缺血接受截肢手术的SSc患者进行的回顾性研究。
9例患者中有5例存在组织学血管炎，其中4例有aCL抗体，不过抗体滴度不高。
血管炎确实在SSc中出现，至少在有严重外周缺血的亚组中如此。这些发现可能对该亚组SSc患者的治疗有影响。
