Rodolico A, Borruso L, Corrier M, Scalia E, Frazzetta M, Incandela S, Lauria B, Mazzarese S, Melloni D, Sanfilippo M
Istituto di Patologia Chirurgica B, Policlinico Universitario P. Giaccone, Palermo.
G Chir. 1994 Jan-Feb;15(1-2):45-50.
In the present study the efficacy and safety of pefloxacin (400 mg/5 ml vial) intravenously administrated for surgical prophylaxis was assessed. Nine hundred and fifty-two patients were treated (599 M, 343 F), with a mean age of 57.9 years +/- 18.6 SD, and in all cases surgical prophylaxis was carried out according to the following scheme: short-term with 2 vials (800 mg) 1 h before the operation, repeated at 12 and 24 hours after the operation; long-term 2 vials (800 mg) 1 h before the operation repeated at 12 and 24 hours after the operation and followed by 1 vial every 12 h for other 2 days. The choice between the two schemes was conditioned by the type of operation and by the basic conditions of the patient. Pefloxacin was seen to be effective in preventing the onset of post-surgical infections (97%), also maintaining the clinical parameters considered within normal limits. Safety was also highly satisfactory, since only 22 (2.3%) cases of side effects occurred, particularly involving the gastro-intestinal system. Thus, in conclusion, the validity of pefloxacin in surgical prophylaxis, with special emphasis on its efficacy in elderly and compromised patients is asserted.
在本研究中，评估了静脉注射培氟沙星（400毫克/5毫升小瓶）用于手术预防的有效性和安全性。共治疗了952例患者（男性599例，女性343例），平均年龄57.9岁±18.6标准差，所有病例均按照以下方案进行手术预防：短期方案为术前1小时静脉注射2瓶（800毫克），术后12小时和24小时重复注射；长期方案为术前1小时静脉注射2瓶（800毫克），术后12小时和24小时重复注射，随后每12小时注射1瓶，持续2天。两种方案的选择取决于手术类型和患者的基本状况。培氟沙星在预防术后感染方面被证明是有效的（97%），同时也能将所考虑的临床参数维持在正常范围内。安全性也非常令人满意，因为仅发生了22例（2.3%）副作用病例，尤其涉及胃肠道系统。因此，总之，培氟沙星在手术预防中的有效性得到了肯定，尤其强调了其在老年患者和身体状况不佳患者中的疗效。
