Zhou G P, Guo Y Q, Ji Y H, Zhang G L
Division of Nephrology, Children's Hospital, Shanghai Medical University, China.
Pediatr Nephrol. 1994 Apr;8(2):140-1. doi: 10.1007/BF00865460.
Steroid-sensitive nephrotic syndrome (SSNS) has been postulated to have an immunopathogenic basis. To determine whether SSNS is associated with specific class II antigens of the major histocompatibility complex, we studied HLA-DR and DQ in 40 children with SSNS. HLA-DR7 was found in 40% of SSNS patients compared with only 11.23% of controls (P = 0.00025). HLA-DR9 occurred in 71.40% of patients with frequent relapses, compared with 27.37% of controls (P = 0.016). It seems likely that SSNS has an immunogenetic basis.
类固醇敏感性肾病综合征（SSNS）被推测具有免疫致病基础。为了确定SSNS是否与主要组织相容性复合体的特定II类抗原相关，我们研究了40例SSNS患儿的HLA - DR和DQ。40%的SSNS患者中发现了HLA - DR7，而对照组中仅为11.23%（P = 0.00025）。频繁复发的患者中71.40%出现HLA - DR9，而对照组为27.37%（P = 0.016）。SSNS似乎具有免疫遗传基础。
