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利用单纯疱疹病毒胸苷激酶基因/更昔洛韦系统进行体内肿瘤转导的恶性脑肿瘤基因治疗。

Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.

作者信息

Culver K W, Van Gilder J, Link C J, Carlstrom T, Buroker T, Yuh W, Koch K, Schabold K, Doornbas S, Wetjen B

出版信息

Hum Gene Ther. 1994 Mar;5(3):343-79. doi: 10.1089/hum.1994.5.3-343.

DOI:10.1089/hum.1994.5.3-343
PMID:8018748
Abstract

Murine retroviral vectors can infect a wide variety of proliferating mammalian cell types (e.g. lymphocytes). Non-proliferating tissues (e.g. neurons) are not transduced by murine retroviral vectors. These findings suggest that this type of vector may be useful for the selective introduction of genes into growing tumors in the brain, since the tumor is essentially the only tissue that will integrate and express the vector genes.

摘要

鼠逆转录病毒载体可感染多种增殖性哺乳动物细胞类型（如淋巴细胞）。非增殖性组织（如神经元）不会被鼠逆转录病毒载体转导。这些发现表明，这类载体可能有助于将基因选择性地导入脑部生长的肿瘤中，因为肿瘤基本上是唯一会整合并表达载体基因的组织。

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Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.利用单纯疱疹病毒胸苷激酶基因/更昔洛韦系统进行体内肿瘤转导的恶性脑肿瘤基因治疗。
Hum Gene Ther. 1994 Mar;5(3):343-79. doi: 10.1089/hum.1994.5.3-343.
2
Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.重组腺病毒H5.010RSVTK治疗晚期中枢神经系统恶性肿瘤：一项I期试验。
Hum Gene Ther. 1996 Aug 1;7(12):1465-82. doi: 10.1089/hum.1996.7.12-1465.
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Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir.使用胸苷激酶基因进行肿瘤内转导并静脉注射更昔洛韦的脑肿瘤基因治疗。
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In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.原位逆转录病毒介导的基因转移用于治疗大鼠脑肿瘤。
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Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.体内单纯疱疹病毒胸苷激酶基因转导及更昔洛韦治疗对抑制小鼠和人黑色素瘤细胞以及大鼠胶质母细胞瘤细胞肿瘤生长的不同疗效。
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Toxicity studies and distribution dynamics of retroviral vectors following intrathecal administration of retroviral vector-producer cells.鞘内注射逆转录病毒载体生产细胞后逆转录病毒载体的毒性研究及分布动态
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In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors.人白细胞介素-2基因的体内转移：对实验性脑肿瘤的肿瘤杀伤阴性结果。
J Neurosurg. 1994 Mar;80(3):535-40. doi: 10.3171/jns.1994.80.3.0535.
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The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats.胸苷激酶转导和更昔洛韦治疗对大鼠9L胶质瘤肿瘤血管及生长的影响。
J Neurosurg. 1994 Aug;81(2):256-60. doi: 10.3171/jns.1994.81.2.0256.
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Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system.
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Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.携带脑肿瘤的大鼠经更昔洛韦和保留完整胸苷激酶基因的单纯疱疹病毒载体治疗后的长期存活情况。
Cancer Res. 1994 Nov 15;54(22):5745-51.

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