Suárez A, Ramírez M C, Gil A, Faus M J
Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Granada, España.
Nutr Hosp. 1994 May-Jun;9(3):170-80.
Dietary supplement with long-chain polyunsaturated fatty acids from the series n-3 and n-5 appears to be advisable in the nutritional repletion of a variety of conditions. It must be associated with the addition of a sufficient amount of an anti-oxidant to prevent the oxidative degradation of such fatty acids. The purpose of this study was to appraise the effect of the dietary addition of long-chain polyunsaturated fatty acids from the series n-3 and n-5 and of Vitamin E on the fatty acid profile of the plasma, and its lipidic fractions. Five groups of weaning rats were fed for a month as follows: Group A, a semipurified diet with 10% of fat [18:1(n-9) 40%; 18:2(n-6) 12%; 18:3(n-3) 1.2%]; Groups B and C, a semipurified diet with 7% of fat A and 3% of a marine oil concentrate; Groups D and E, a semipurified diet with 7% of fat A, 1.5% of a marine oil concentrate and 1.5% of a phospholipid concentrate of animal origin. Groups B and D were supplemented with 0.5 g of Vitamin E per kilogram of fat. The results obtained suggest that dietary supplement is necessary with long-chain polyunsaturated fatty acids from both the n-3 and n-5 series in order to maintain plasmatic levels of 20:4(n-6) and of 22:6(n-3) in the face of the tissular inability to produce them from their dietary precursors [18:2(n-6) and 18:3)], along with Vitamin E to prevent the oxidative malnutrition of these fatty acids.
补充含有n - 3和n - 5系列长链多不饱和脂肪酸的膳食补充剂，对于多种情况下的营养补充似乎是可取的。必须添加足够量的抗氧化剂，以防止此类脂肪酸的氧化降解。本研究的目的是评估膳食中添加n - 3和n - 5系列长链多不饱和脂肪酸以及维生素E对血浆脂肪酸谱及其脂质组分的影响。五组断奶大鼠喂养一个月，具体如下：A组，含10%脂肪的半纯化日粮[18:1(n - 9) 40%；18:2(n - 6) 12%；18:3(n - 3) 1.2%]；B组和C组，含7%脂肪A和3%海洋油浓缩物的半纯化日粮；D组和E组，含7%脂肪A、1.5%海洋油浓缩物和1.5%动物源性磷脂浓缩物的半纯化日粮。B组和D组每千克脂肪补充0.5 g维生素E。所得结果表明，为了在组织无法从膳食前体[18:2(n - 6)和18:3)]生成20:4(n - 6)和22:6(n - 3)的情况下维持血浆水平，有必要补充n - 3和n - 5系列的长链多不饱和脂肪酸，同时补充维生素E以防止这些脂肪酸的氧化营养不良。
