Perry E K, Haroutunian V, Davis K L, Levy R, Lantos P, Eagger S, Honavar M, Dean A, Griffiths M, McKeith I G
MRC Neurochemical Pathology Unit, Newcastle General Hospital, UK.
Neuroreport. 1994 Mar 21;5(7):747-9. doi: 10.1097/00001756-199403000-00002.
Activity of the enzyme which synthesizes acetylcholine, choline acetyltransferase, was estimated in the neocortex of three series of control and demented cases. Clinically demented cases were divided into those with the classical neuropathological features of Alzheimer's disease (numerous neocortical plaques and tangles) and those with Lewy bodies in the brain stem and cortex (together with plaques and variable neurofibrillary pathology). In the Lewy body cases neocortical choline acetyltransferase was consistently lower than in the classical Alzheimer-type cases. Two of the Lewy body cases with extremely low cholinergic activity were responders in therapeutic trials of the cholinesterase inhibitor, tacrine, and the combined data suggest that cholinergic therapy may be particularly relevant to patients with Lewy body type dementia.
在三组对照病例和痴呆病例的新皮质中，对合成乙酰胆碱的酶——胆碱乙酰转移酶的活性进行了评估。临床痴呆病例被分为具有阿尔茨海默病典型神经病理学特征（大量新皮质斑块和缠结）的病例，以及脑干和皮质中有路易体（伴有斑块和可变的神经原纤维病理改变）的病例。在路易体病例中，新皮质胆碱乙酰转移酶始终低于典型阿尔茨海默型病例。在胆碱酯酶抑制剂他克林的治疗试验中，两名胆碱能活性极低的路易体病例有反应，综合数据表明胆碱能治疗可能与路易体型痴呆患者特别相关。
