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Prognostic value of a solubilized fraction of EGF receptors in primary breast cancer using an immunoenzymatic assay--a retrospective study.

作者信息

Spyratos F, Martin P M, Hacène K, Andrieu C, Romain S, Floiras J L, Magdelénat H

机构信息

Centre René Huguenin, Saint-Cloud, France.

出版信息

Breast Cancer Res Treat. 1994 Jan;29(1):85-95. doi: 10.1007/BF00666184.

DOI:10.1007/BF00666184
PMID:8018965
Abstract

In a retrospective study of 319 primary breast cancers, we show that an immunoenzymatic assay of a solubilized fraction of EGF receptors indicates a prognostic value for EGFR which is in contradiction with some (but not all) other studies. It appears that different methodological approaches of measuring EGFR are not equivalent in terms of prognostic power. We emphasize the need for rigorous multicentric standardization and quality control of assays, followed by multistep validation of parameters oriented towards clinical use.

摘要

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本文引用的文献

1
EGF-R and steroid receptors in breast cancer: a comparison with tumor grading, tumor size, lymph node involvement, and age.乳腺癌中的表皮生长因子受体（EGF-R）和类固醇受体：与肿瘤分级、肿瘤大小、淋巴结受累情况及年龄的比较
Clin Biochem. 1993 Jun;26(3):221-7. doi: 10.1016/0009-9120(93)90029-6.
2
Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies.阿霉素与抗表皮生长因子受体单克隆抗体联合使用的抗肿瘤作用。
J Natl Cancer Inst. 1993 Aug 18;85(16):1327-33. doi: 10.1093/jnci/85.16.1327.
3
Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.
表皮生长因子对A431细胞的生长刺激作用：利用抗受体单克隆抗体鉴定表皮生长因子的高亲和力受体
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1337-41. doi: 10.1073/pnas.80.5.1337.
4
Revision of the standards for the assessment of hormone receptors in human breast cancer; report of the second E.O.R.T.C. Workshop, held on 16-17 March, 1979, in the Netherlands Cancer Institute.人类乳腺癌激素受体评估标准的修订；1979年3月16 - 17日于荷兰癌症研究所召开的第二届欧洲癌症研究与治疗组织研讨会报告
Eur J Cancer (1965). 1980 Nov;16(11):1513-5. doi: 10.1016/0014-2964(80)90064-x.
5
Epidermal growth factor receptors in human breast cancer.人类乳腺癌中的表皮生长因子受体
Breast Cancer Res Treat. 1984;4(3):189-93. doi: 10.1007/BF01806484.
6
Evaluation of survival data and two new rank order statistics arising in its consideration.生存数据的评估以及在考虑过程中出现的两个新的排序统计量。
Cancer Chemother Rep. 1966 Mar;50(3):163-70.
7
Epidermal growth factor receptor in human breast cancers: correlation with estrogen and progesterone receptors.人类乳腺癌中的表皮生长因子受体：与雌激素和孕激素受体的相关性
Breast Cancer Res Treat. 1988 May;11(2):173-8. doi: 10.1007/BF01805841.
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Quantitative assays of epidermal growth factor receptor in human breast cancer: cut-off points of clinical relevance.人乳腺癌中表皮生长因子受体的定量检测：具有临床相关性的临界值
Int J Cancer. 1988 Jul 15;42(1):36-41. doi: 10.1002/ijc.2910420108.
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Epidermal growth factor receptor in human breast cancer: correlation with steroid hormone receptors and axillary lymph node involvement.
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Lancet. 1987 Jun 20;1(8547):1398-402. doi: 10.1016/s0140-6736(87)90593-9.