孕期吸烟与先天性肢体缺陷
Smoking during pregnancy and congenital limb deficiency.
作者信息
Czeizel A E, Kodaj I, Lenz W
机构信息
Department of Human Genetics and Teratology, National Institute of Hygiene-WHO Collaborating Centre for Community Control of Hereditary Diseases, Budapest, Hungary.
出版信息
BMJ. 1994 Jun 4;308(6942):1473-6. doi: 10.1136/bmj.308.6942.1473.
OBJECTIVE
To examine genetic and environmental factors in the origin of isolated congenital limb deficiencies.
DESIGN
Case-control study with questionnaire at a family interview of cases of isolated congenital limb deficiencies (six types), negative controls (matched for age, sex, and place of residence), and positive controls (cases of sentinel anomalies).
SETTING
The database of the Hungarian Congenital Abnormality Registry, 1975-84, complemented by three other sources of ascertainment (1,575,904 births).
SUBJECTS
537 case-control pairs; 392 positive controls.
MAIN OUTCOME MEASURES
Smoking during pregnancy, congenital limb deficiencies.
RESULTS
The adjusted rate of smoking during pregnancy was significantly higher in the mothers of cases of terminal transverse defect (relative odds 1.48; 95% confidence interval 0.98 to 2.23; P = 0.017). This finding supports the hypothesis of vascular disruption as a cause of congenital limb deficiency.
CONCLUSIONS
Maternal smoking during pregnancy raises the relative odds for terminal transverse limb deficiencies.
目的
研究孤立性先天性肢体缺损的遗传和环境因素。
设计
采用病例对照研究，通过问卷调查对孤立性先天性肢体缺损（六种类型）病例、阴性对照（按年龄、性别和居住地点匹配）和阳性对照（哨兵畸形病例）进行家庭访谈。
设置
匈牙利先天性异常登记数据库，时间跨度为1975 - 1984年，并辅以其他三种确诊来源（1,575,904例出生病例）。
研究对象
537对病例对照；392例阳性对照。
主要观察指标
孕期吸烟、先天性肢体缺损。
结果
末端横向缺损病例的母亲孕期吸烟调整率显著更高（相对比值1.48；95%置信区间0.98至2.23；P = 0.017）。这一发现支持血管破坏是先天性肢体缺损病因的假说。
结论
孕期母亲吸烟会增加末端横向肢体缺损的相对几率。
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