[The occurrence of immunological tolerance to inhibitors of factors VIII and IX in hemophilia patients].

To abolish inhibitors, 40 out of 60 hemophiliacs (57 patients and 3 with hemophilia A and B, respectively) were treated according to the therapeutic scheme specified as Bonn protocol. A complete disappearance of the inhibitors was achieved in all the patients. These were followed up for 13 years during which they received on demand standard hemostatic treatment. No inhibitors have been registered so far.