Bervoets K, Schlenzig J S, Böhles H
Zentrum der Kinderheilkunde, Allgemeine Pädiatrie I, Universität Frankfurt/M.
Fortschr Med. 1994 May 10;112(13):192-4.
The fact that almost all neonates exhibit a "physiological" jaundice, prompts the question whether bilirubin, usually exclusively considered a potentially toxic endproduct of the metabolism of heme, might not also have a positive task in the first days of life. A recently discovered property of bilirubin under in vitro conditions is its ability to combine with free oxygen radicals such as are produced in the oxidative metabolic processes of the neonate immediately following birth. In the present article, the concept of the anti-oxidative effect of bilirubin, and its translation to the early neonatal period is presented and discussed on the basis of a number of examples.
几乎所有新生儿都会出现“生理性”黄疸，这一事实引发了一个问题：胆红素通常被认为只是血红素代谢的潜在有毒终产物，在生命的最初几天它是否也可能具有积极作用。胆红素在体外条件下最近被发现的一个特性是它能够与自由基结合，比如新生儿出生后立即在氧化代谢过程中产生的自由基。在本文中，基于一些实例，介绍并讨论了胆红素抗氧化作用的概念及其在新生儿早期的意义。
