Lou X Y, Nishi Y, Haji M, Antoku Y, Tanaka S, Ikuyama S, Yanase T, Takayanagi R, Nawata H
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Fukuoka Igaku Zasshi. 1994 May;85(5):168-74.
To clarify the Sertoli cell and Leydig cell function in hypogonadic male patients with myotonic dystrophy (DM), serum concentrations of inhibin, total testosterone (TT), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay in 6 male DM patients (41 to 56 years old, 47.7 +/- 5.05 years old) and compared with those in normal adult men. In 116 healthy men aged from 24 to 92 years, serum inhibin and TT levels decreased and serum FSH and LH concentrations increased with advancing age. There was an inverse correlation between serum inhibin and FSH. These results support the concept of negative feedback regulation system of FSH secretion by inhibin. Male DM patients showed significantly lower serum TT and higher concentrations of FSH and LH, compared with the age-matched 39 normal adult men (49-59 years old, 48.2 +/- 6.14 years old). However, there was no significant difference in serum inhibin levels between the patients and normal counterparts. These results indicate that the Sertoli cell function is reserved in male DM patient, although the Leydig cell function is impaired. It is also suggested that in these patients a negative feedback control system between inhibin and FSH may be disordered to some extent.
为阐明强直性肌营养不良（DM）性腺功能减退男性患者的支持细胞和间质细胞功能，采用放射免疫分析法测定了6例男性DM患者（年龄41至56岁，平均47.7±5.05岁）血清抑制素、总睾酮（TT）、促卵泡激素（FSH）和促黄体生成素（LH）的浓度，并与正常成年男性进行比较。在116例年龄24至92岁的健康男性中，血清抑制素和TT水平随年龄增长而降低，血清FSH和LH浓度随年龄增长而升高。血清抑制素与FSH之间呈负相关。这些结果支持抑制素对FSH分泌负反馈调节系统的概念。与年龄匹配的39例正常成年男性（年龄49至59岁，平均48.2±6.14岁）相比，男性DM患者血清TT显著降低，FSH和LH浓度升高。然而，患者与正常对照者血清抑制素水平无显著差异。这些结果表明，男性DM患者支持细胞功能保留，但间质细胞功能受损。还提示在这些患者中，抑制素与FSH之间的负反馈控制系统可能在一定程度上紊乱。
