原发性胆汁性肝硬化的癌症风险：一项来自瑞典的基于人群的研究。
Cancer risk in primary biliary cirrhosis: a population-based study from Sweden.
作者信息
Lööf L, Adami H O, Sparén P, Danielsson A, Eriksson L S, Hultcrantz R, Lindgren S, Olsson R, Prytz H, Ryden B O
机构信息
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
出版信息
Hepatology. 1994 Jul;20(1 Pt 1):101-4.
A cohort of 559 patients in Sweden who satisfied predetermined criteria for the diagnosis of primary biliary cirrhosis was followed with respect to the incidence of cancer during the period of 1958 to 1988. The mean follow-up time from the time of primary biliary cirrhosis diagnosis was 9.0 +/- 5.4 yr. During the follow-up period, 148 patients died and the primary cause of death was liver insufficiency. An overall excess risk for cancer, standardized incidence ratio 1.6; 95% confidence interval, 1.1 to 2.2, was found in the cohort. In contrast to previous reports, we found no excess risk for breast cancer (standardized incidence ratio, 0.9; 95% confidence interval, 0.3 to 2.1). The number of hepatocellular cancers in the primary biliary cirrhosis cohort did not significantly differ from expected (standardized incidence ratio, 2.91; 95% confidence interval, 0.4 to 10.5).
在瑞典，对559名符合原发性胆汁性肝硬化诊断预定标准的患者进行队列研究，随访其在1958年至1988年期间的癌症发病率。自原发性胆汁性肝硬化诊断之时起，平均随访时间为9.0±5.4年。随访期间，148名患者死亡，主要死因是肝功能不全。该队列中发现总体癌症风险增加，标准化发病率比为1.6；95%置信区间为1.1至2.2。与之前的报告不同，我们未发现乳腺癌风险增加（标准化发病率比为0.9；95%置信区间为0.3至2.1）。原发性胆汁性肝硬化队列中的肝细胞癌数量与预期无显著差异（标准化发病率比为2.91；95%置信区间为0.4至10.5）。
Zotero 插件