Hasegawa Y, Matsuura H
Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Head Neck. 1994 Mar-Apr;16(2):173-80. doi: 10.1002/hed.2880160212.
The purpose of this study was to investigate the incidence of metastases to retropharyngeal (RP) nodes and to evaluate the results of RP node dissections in advanced carcinomas of the oropharynx and hypopharynx. Twenty-four patients with stage III/IV squamous cell carcinomas of the oropharynx and hypopharynx were treated with standard resection, RP node dissection up to the base of the skull, and radiotherapy of 50 Gy postoperatively to the RP space if RP nodes were involved. Fifty percent (12 of 24) of the patients had positive RP nodes, 36% (4/11) with carcinoma of the oropharynx and 62% (8/13) with carcinoma of the hypopharynx. Six patients had recurrences and of them five died of the disease. The cumulative 3-year survival rate (Kaplan-Meier) was 53%. Because of the high incidence of metastases to RP nodes in stage III/IV oropharynx and hypopharyngeal cancers, we recommend the adding of RP node dissection in these patients.
本研究的目的是调查咽后（RP）淋巴结转移的发生率，并评估口咽和下咽晚期癌患者RP淋巴结清扫的结果。24例口咽和下咽III/IV期鳞状细胞癌患者接受了标准切除术、至颅底的RP淋巴结清扫术，若RP淋巴结受累，则术后对RP间隙进行50 Gy的放射治疗。50%（24例中的12例）患者的RP淋巴结呈阳性，口咽癌患者中36%（11例中的4例）呈阳性，下咽癌患者中62%（13例中的8例）呈阳性。6例患者复发，其中5例死于该病。累积3年生存率（Kaplan-Meier法）为53%。由于III/IV期口咽癌和下咽癌患者中RP淋巴结转移的发生率较高，我们建议在这些患者中增加RP淋巴结清扫术。
