Baumgartner R W, Regard M
Neurological Department, Heinrich-Heine University, Düsseldorf, Germany.
J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):814-7. doi: 10.1136/jnnp.57.7.814.
Previous studies on CO2 reactivity in cerebral low flow infarcts (LFIs) included patients with lesions in the frontoparasagittal area, supraganglionic white matter, and temporoparieto-occipital zone. Supraganglionic white matter LFIs are, however, difficult to separate from non-low flow induced infarcts of the lacunar type, and temporoparieto-occipital LFIs from infarcts in the territory of the inferior stem of the middle cerebral artery. The CO2 reactivity of the middle cerebral artery was studied in 56 patients with high grade stenoses and occlusions of the internal carotid artery and LFIs (n = 9) in the frontoparasagittal border zone, territorial infarcts (n = 26), no infarcts (n = 21), and normal subjects (n = 25) by means of transcranial Doppler sonography. The aim was to investigate whether patients with LFIs have significantly lower CO2 reactivity than patients with territorial infarcts, no infarcts, and normal subjects. Patients with LFIs had the most severely reduced CO2 reactivity on the symptomatic side and CO2 reactivity was significantly lower than on the asymptomatic side. It was also lower than in patients with unilateral and bilateral internal carotid artery obstructions and territorial infarcts, asymptomatic patients, and healthy volunteers. It is concluded that LFIs are associated with significantly reduced CO2 reactivity.
先前关于脑低灌注梗死（LFIs）中二氧化碳反应性的研究纳入了额旁矢状区、神经节上白质和颞顶枕区有病变的患者。然而，神经节上白质LFIs很难与腔隙性非低灌注性梗死区分开来，颞顶枕区LFIs也很难与大脑中动脉下干供血区的梗死区分开来。通过经颅多普勒超声对56例颈内动脉高度狭窄和闭塞且在前额旁矢状交界区有LFIs（n = 9）、区域梗死（n = 26）、无梗死（n = 21）的患者以及正常受试者（n = 25）的大脑中动脉二氧化碳反应性进行了研究。目的是调查LFIs患者的二氧化碳反应性是否显著低于区域梗死患者、无梗死患者和正常受试者。LFIs患者症状侧的二氧化碳反应性降低最为严重，且症状侧的二氧化碳反应性显著低于无症状侧。它也低于单侧和双侧颈内动脉阻塞及区域梗死患者、无症状患者和健康志愿者。研究得出结论，LFIs与二氧化碳反应性显著降低有关。
