NG-硝基-L-精氨酸甲酯抑制H3组胺能受体激动剂对豚鼠灌注细支气管非肾上腺素能非胆碱能收缩的作用。
NG-nitro-L-arginine methyl ester inhibits the effect of an H3-histaminergic receptor agonist on NANC contraction in guinea-pig perfused bronchioles.
作者信息
Burgaud J L, Oudart N
机构信息
Laboratoire de Pharmacologie, UFR de Pharmacie, Limoges, France.
出版信息
J Pharm Pharmacol. 1994 Feb;46(2):153-5. doi: 10.1111/j.2042-7158.1994.tb03762.x.
A role for nitric oxide in the H3-histaminergic agonist-induced inhibition of the non-adrenergic, non-cholinergic (NANC) contraction has been studied in guinea-pig perfused bronchioles. (R)-alpha-Methylhistamine ((R)-alpha-MeHA), an agonist for H3 receptors, inhibited the NANC contraction induced by electrical field stimulation. NG-Nitro-L-arginine methyl ester (L-NAME) (50 microM), an inhibitor of nitric oxide synthesis, blocked the effect of (R)-alpha-MeHA. The effect of L-NAME was reversed by L-arginine (50 microM). L-NAME, L-arginine or (R)-alpha-MeHA were without effect on exogenous substance P- or neurokinin A-induced contractile responses of the perfused bronchioles. These results show that an H3-agonist inhibited the release of neurotransmitters in NANC nerve endings of guinea-pig perfused bronchioles presumably by production of nitric oxide.
在豚鼠灌注细支气管中，已对一氧化氮在H3组胺能激动剂诱导的非肾上腺素能、非胆碱能（NANC）收缩抑制中的作用进行了研究。H3受体激动剂（R）-α-甲基组胺（（R）-α-MeHA）抑制电场刺激诱导的NANC收缩。一氧化氮合成抑制剂NG-硝基-L-精氨酸甲酯（L-NAME）（50微摩尔）阻断了（R）-α-MeHA的作用。L-精氨酸（50微摩尔）可逆转L-NAME的作用。L-NAME、L-精氨酸或（R）-α-MeHA对外源性P物质或神经激肽A诱导的灌注细支气管收缩反应均无影响。这些结果表明，H3激动剂可能通过产生一氧化氮来抑制豚鼠灌注细支气管NANC神经末梢中神经递质的释放。
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