Nω-硝基-L-精氨酸和辣椒素对猴离体肠系膜动脉神经源性血管舒缩反应的影响。

Effects of N omega-nitro-L-arginine and capsaicin on neurogenic vasomotor responses in isolated mesenteric arteries of the monkey.

作者信息

Tsuchiya K, Urabe M, Yamamoto R, Asada Y, Lee T J

机构信息

Experimental Animal Center, Miyazaki Medical College, Japan.

出版信息

J Pharm Pharmacol. 1994 Feb;46(2):155-7. doi: 10.1111/j.2042-7158.1994.tb03763.x.

DOI:10.1111/j.2042-7158.1994.tb03763.x

PMID:8021809

Abstract

Monkey isolated mesenteric arterial rings denuded of endothelium constricted upon transmural nerve stimulation (TNS) in the absence of active muscle tone. The constriction was potentiated by N omega-nitro-L-arginine (3 x 10(-5) M), but not by the D-enantiomer (3 x 10(-5) M). The potentiation was reversed by L-arginine (3 x 10(-4) M). The neurogenic vasoconstriction of mesenteric arteries was also augmented by capsaicin, but to a lesser extent than that induced by N omega-nitro-L-arginine. Indomethacin (10(-5) M) did not affect TNS-induced vasoconstriction. These findings suggest that nerve-derived nitric oxide or a related substance may play a greater role than do capsaicin-sensitive vasodilator transmitters in neurogenic regulation of mesenteric arterial tone in the monkey. The transmitter mechanisms for vasodilation in mesenteric circulation vary among species.

摘要

在无主动肌张力的情况下，对去内皮的猴离体肠系膜动脉环进行跨壁神经刺激（TNS）时，动脉环会收缩。Nω-硝基-L-精氨酸（3×10⁻⁵ M）可增强这种收缩，但D-对映体（3×10⁻⁵ M）则无此作用。L-精氨酸（3×10⁻⁴ M）可逆转这种增强作用。辣椒素也可增强肠系膜动脉的神经源性血管收缩，但程度小于Nω-硝基-L-精氨酸所致。吲哚美辛（10⁻⁵ M）不影响TNS诱导的血管收缩。这些发现表明，在猴肠系膜动脉张力的神经源性调节中，神经源性一氧化氮或相关物质可能比辣椒素敏感的血管舒张递质发挥更大作用。肠系膜循环中血管舒张的递质机制因物种而异。