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Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells.

作者信息

John C S, Vilner B J, Bowen W D

机构信息

Department of Radiology, George Washington University Medical Center, Washington, D.C. 20037.

出版信息

J Med Chem. 1994 Jun 10;37(12):1737-9. doi: 10.1021/jm00038a002.

DOI:10.1021/jm00038a002
PMID:8021913
Abstract
摘要

相似文献

1
Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells.新型σ受体放射性药物[125I]-N-(N-苄基哌啶-4-基)-4-碘苯甲酰胺的合成与表征：与MCF-7乳腺肿瘤细胞的高亲和力结合
J Med Chem. 1994 Jun 10;37(12):1737-9. doi: 10.1021/jm00038a002.
2
Synthesis and pharmacological characterization of 4-[125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide: a high affinity sigma receptor ligand for potential imaging of breast cancer.4-[125I]-N-(N-苄基哌啶-4-基)-4-碘苯甲酰胺的合成与药理学特性：一种用于乳腺癌潜在成像的高亲和力西格玛受体配体。
Cancer Res. 1995 Jul 15;55(14):3022-7.
3
Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1'-piperidinyl)ethyl]-3-[125I]iodo-4-methoxybenzamide (P[125I]MBA) for imaging breast cancer.用于乳腺癌成像的N-[2-(1'-哌啶基)乙基]-3-[125I]碘-4-甲氧基苯甲酰胺（P[125I]MBA）的合成、体外药理学特性及临床前评价
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Synthesis, in vitro binding, and tissue distribution of radioiodinated 2-[125I]N-(N-benzylpiperidin-4-yl)-2-iodo benzamide, 2-[125I]BP: a potential sigma receptor marker for human prostate tumors.放射性碘化的2-[¹²⁵I]N-(N-苄基哌啶-4-基)-2-碘苯甲酰胺（2-[¹²⁵I]BP）的合成、体外结合及组织分布：一种潜在的人前列腺肿瘤西格玛受体标记物
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Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-iodophenyl)ethyl]-N-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors.[125I]N-[2-(4-碘苯基)乙基]-N-甲基-2-(1-哌啶基)乙胺的合成、体外验证及体内药代动力学：一种用于成像σ受体阳性肿瘤的高亲和力配体
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Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors.将靶向σ受体结合苯甲酰胺作为人类前列腺肿瘤的体内诊断和治疗剂。
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Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.N-(1-苄基哌啶-4-基)苯乙酰胺及相关类似物作为强效和选择性σ1受体配体的合成与定量构效关系
J Med Chem. 1998 Jun 18;41(13):2361-70. doi: 10.1021/jm980032l.
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Substituted halogenated arylsulfonamides: a new class of sigma receptor binding tumor imaging agents.取代卤代芳基磺酰胺：一类新型的σ受体结合肿瘤显像剂。
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Increased binding to sigma sites of N-[1'(2-piperidinyl)ethyl)-4-[I-125]-iodobenzamide (I-125-PAB) with onset of tumor cell proliferation.随着肿瘤细胞增殖的开始，N-[1'（2-哌啶基）乙基]-4-[I-125]-碘苯甲酰胺（I-125-PAB）与σ位点的结合增加。
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