Ichida S, Wada T, Matsuda N, Nakazaki S
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.
Jpn J Pharmacol. 1994 Mar;64(3):209-12. doi: 10.1254/jjp.64.209.
We investigated the effects of various Ca channel agonists (Ca agonist) derived from 1,4-dihydropyridine on KCl-stimulated 45Ca uptake by differentiated and undifferentiated neuroblastoma x glioma hybrid NG108-15 cells with and without dibutyryl cAMP. Ca agonists Bay K 8644, YC-170 and CGP 28392 enhanced KCl-stimulated 45Ca uptake in differentiated NG108-15 cells, but only slightly in undifferentiated NG108-15 cells. The rank order of the enhancing effects was roughly Bay K 8644 > YC-170 > > CGP 28392. These results suggest that there is some difference between the mechanism by which these Ca agonists affect KCl-stimulated 45Ca uptake in differentiated and undifferentiated NG108-15 cells, although the nature of that difference is not clear.
我们研究了源自1,4 - 二氢吡啶的各种钙通道激动剂（钙激动剂）对分化和未分化的神经母细胞瘤x胶质瘤杂交NG108 - 15细胞在有和没有二丁酰环磷腺苷（dibutyryl cAMP）情况下KCl刺激的45Ca摄取的影响。钙激动剂Bay K 8644、YC - 170和CGP 28392增强了分化的NG108 - 15细胞中KCl刺激的45Ca摄取，但在未分化的NG108 - 15细胞中作用轻微。增强作用的顺序大致为Bay K 8644 > YC - 170 > > CGP 28392。这些结果表明，这些钙激动剂影响分化和未分化的NG108 - 15细胞中KCl刺激的45Ca摄取的机制存在一些差异，尽管这种差异的本质尚不清楚。
