Cattan A R, Douglas E
Department of Haematology, University of Newcastle upon Tyne, Royal Victoria Infirmary, U.K.
Leuk Res. 1994 Jul;18(7):513-22. doi: 10.1016/0145-2126(94)90089-2.
Using the C.B.17 scid mouse strain, we have developed a model of disseminated leukaemia and myeloma using five human cell lines, CCRF-Cem, Molt-4, Raji, IM9 and HS-Sultan. Introduction of any of these cell lines by either an intravenous or an intraperitoneal route eventually kills the mouse due to leukaemia or myeloma cell load. Neoplastic cells can be found in the blood, liver and bone marrow. Intraperitoneal transfer produces a local solid tumour whereas intravenous transfer produces foci of neoplastic cells in the spine and brain. A single dose of melphalan is able to increase survival time from infection of a lethal dose of the T-cell leukaemia cell line, CCRF-Cem.
利用C.B.17 scid小鼠品系，我们使用5种人类细胞系CCRF-Cem、Molt-4、Raji、IM9和HS-Sultan建立了一种播散性白血病和骨髓瘤模型。通过静脉或腹腔途径引入这些细胞系中的任何一种，最终都会因白血病或骨髓瘤细胞负荷而导致小鼠死亡。肿瘤细胞可在血液、肝脏和骨髓中发现。腹腔转移会产生局部实体瘤，而静脉转移会在脊柱和大脑中产生肿瘤细胞灶。单剂量美法仑能够延长感染致死剂量的T细胞白血病细胞系CCRF-Cem后的存活时间。
