寄生蠕虫耐药性的分子机制

Molecular aspects of drug resistance in parasitic helminths.

作者信息

Roos M H, Kwa M S, Veenstra J G, Kooyman F N, Boersema J H

机构信息

Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.

出版信息

Pharmacol Ther. 1993 Nov;60(2):331-6. doi: 10.1016/0163-7258(93)90014-5.

DOI:10.1016/0163-7258(93)90014-5

PMID:8022863

Abstract

Parasitic helminths (worms) cause serious infectious diseases in humans and animals. As control of these infections relies mostly on chemotherapeutics, the anthelmintics, resistance has developed against most of these drugs in several parasite species. These resistant parasites are being used to elucidate the molecular mechanisms of drug action.

摘要

寄生性蠕虫会在人类和动物身上引发严重的传染病。由于这些感染的控制主要依赖于化学疗法，即驱虫药，在几种寄生虫物种中，大多数这类药物已经产生了抗药性。这些具有抗药性的寄生虫正被用于阐明药物作用的分子机制。