Wacker J, Müller J, Grischke E M, Unkels R, Bastert G
Frauenklinik, Universität Heidelberg.
Zentralbl Gynakol. 1994;116(5):271-3.
Urapidil is an antagonist of postsynaptic alpha 1 receptors, which leads to a diminution of the increased blood pressure by reducing the peripheral vascular resistance. With this pilot study we examined, whether it is possible to reduce the pregnancy-induced-hypertension with urapidil postpartum. The postpartum dosage of dihydralazine was diminished step by step and finally discontinued. We started i.v. treatment with urapidil at a diastolic blood pressure of more than 100 mm Hg. We observed a declining blood pressure in all cases without any tachycardia or serious side effects. Further studies will have to classify the rank of urapidil in the treatment of hypertension in preeclampsia.
乌拉地尔是一种突触后α1受体拮抗剂，通过降低外周血管阻力来降低升高的血压。在这项初步研究中，我们检验了产后使用乌拉地尔降低妊娠高血压是否可行。产后逐步减少肼屈嗪的剂量，最终停用。当舒张压超过100 mmHg时，我们开始静脉注射乌拉地尔治疗。我们观察到所有病例的血压均下降，且无任何心动过速或严重副作用。进一步的研究将必须确定乌拉地尔在子痫前期高血压治疗中的地位。
