Ungvari G S, Leung C M, Wong M K, Lau J
Department of Psychiatry, Chinese University of Hong Kong.
Acta Psychiatr Scand. 1994 Apr;89(4):285-8. doi: 10.1111/j.1600-0447.1994.tb01515.x.
During a 5-month period, 18 (8%) of 212 patients admitted to a psychiatric unit affiliated to a teaching hospital were found to have a catatonic syndrome associated with various nonorganic mental disorders. Signs and symptoms of motor retardation predominated the clinical presentations. In the course of a prospective, open study, all 18 patients were challenged by a small dose of oral lorazepam or intramuscular diazepam. Catatonic signs and symptoms in 2 patients showed an immediate, complete, and sustained response to the medication. The remaining 16 patients were maintained on 1 of the 2 benzodiazepines for the next 48 h when their motor status was re-evaluated. Significant clinical improvement was detected in all but 2 patients. However, 9 patients needed electroconvulsive treatment to achieve further improvement. Short-term benzodiazepine administration proved to be a safe and effective treatment of the catatonic syndrome.
在5个月的时间里，一家教学医院附属精神科收治的212名患者中有18名（8%）被发现患有与各种非器质性精神障碍相关的紧张症综合征。运动迟缓的体征和症状在临床表现中占主导地位。在一项前瞻性开放性研究过程中，所有18名患者均接受了小剂量口服劳拉西泮或肌肉注射地西泮的挑战。2名患者的紧张症体征和症状对药物治疗表现出即时、完全且持续的反应。其余16名患者在接下来的48小时内持续使用两种苯二氮䓬类药物中的一种，之后对其运动状态进行重新评估。除2名患者外，所有患者均有显著的临床改善。然而，有9名患者需要接受电休克治疗以实现进一步改善。短期使用苯二氮䓬类药物被证明是治疗紧张症综合征的一种安全有效的方法。
