Vandenesch F, Etienne J
Laboratoire de microbiologie, hôpital Louis-Pradel, BP Lyon-Montchat.
Arch Mal Coeur Vaiss. 1993 Dec;86(12 Suppl):1807-10.
The bacteria causing infective endocarditis have not changed significantly despite the diversity of potential portals of entry. Streptococci (viridans) cause 35 to 45% of cases of endocarditis. Group D streptococci of gastrointestinal origin cause about 20% of cases of endocarditis: Streptococcus bovis is the most commonly isolated species followed by the enterococcus. The beta-haemolytic streptococci of Groups A, B, C and G are rarely isolated. Seventeen to thirty per cent of endocarditis is caused by staphylococci, above all Staphylococcus aureus. These infections are mainly observed in patients with prosthetic valves or intravenous catheters and in intravenous drug addicts. With respect to gram-negative bacilli, enterobacteria are rarely responsible for endocarditis and those of the HACEK group (Haemophilus, Actinobacillus, Cardiobacterium, etc.) were isolated in 3% of cases. Q fever and Chlamydia endocarditis are rare, as are fungal infections usually due to Candida. Endocarditis with negative blood cultures is still observed in about 10% of cases.
尽管潜在的感染途径多种多样,但引起感染性心内膜炎的细菌并没有显著变化。草绿色链球菌引起35%至45%的心内膜炎病例。源自胃肠道的D组链球菌引起约20%的心内膜炎病例:牛链球菌是最常分离出的菌种,其次是肠球菌。A、B、C和G组的β溶血性链球菌很少被分离出来。17%至30%的心内膜炎由葡萄球菌引起,尤其是金黄色葡萄球菌。这些感染主要见于人工瓣膜或静脉导管患者以及静脉吸毒者。关于革兰氏阴性杆菌,肠杆菌很少导致心内膜炎,HACEK组(嗜血杆菌属、放线杆菌属、心杆菌属等)在3%的病例中被分离出来。Q热和衣原体心内膜炎很少见,通常由念珠菌引起的真菌感染也很少见。约10%的病例仍观察到血培养阴性的心内膜炎。