Bonsib S M, Bromley C
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Arch Pathol Lab Med. 1994 Jul;118(7):702-4.
Band 3 protein is an anion-exchange protein that in the human kidney is restricted to a subpopulation of collecting duct-intercalated cells; however, it is absent in the metanephric-derived cells of the nephron. We have studied band 3 protein expression in a series of 60 renal tumors that included 10 oncocytomas, 42 renal cell carcinomas, and eight nephroblastomas by using frozen tumors and a monoclonal antibody. We detected band 3 protein expression in nine of 10 oncocytomas but not in any renal cell carcinomas or nephroblastomas. This finding confirms that band 3 protein is a specific marker for oncocytoma and therefore may have a potential diagnostic application. It also supports the contention that renal cell carcinoma and oncocytoma are histogenically unrelated; the former is metanephric blastema derived and the latter is ampullary bud derived.
带3蛋白是一种阴离子交换蛋白，在人类肾脏中仅限于集合管闰细胞亚群；然而，在肾单位的后肾来源细胞中不存在。我们使用冷冻肿瘤和单克隆抗体，研究了一系列60例肾肿瘤中带3蛋白的表达，这些肿瘤包括10例嗜酸细胞瘤、42例肾细胞癌和8例肾母细胞瘤。我们在10例嗜酸细胞瘤中的9例中检测到带3蛋白表达，但在任何肾细胞癌或肾母细胞瘤中均未检测到。这一发现证实带3蛋白是嗜酸细胞瘤的特异性标志物，因此可能具有潜在的诊断应用价值。它也支持肾细胞癌和嗜酸细胞瘤在组织发生上无关的观点；前者源自后肾胚基，后者源自壶腹芽。
