Hoon V, Thung S N, Kaneko M, Unger P D
Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, City University of New York, NY 10029.
Arch Pathol Lab Med. 1994 Jul;118(7):732-4.
Recent reports have elucidated the variety of tissue types that can react with HMB-45. Consistent positivity has been demonstrated in angiomyolipomas, but only in the smooth-muscle cells. In this report, we examine five renal angiomyolipomas and 20 mesenchymal lesions with similar morphological features and with a possibly similar histogenesis. These include one retroperitoneal lymphangioleiomyomatosis, five epithelioid leiomyomas, nine leiomyosarcomas with epithelioid features, and five alveolar soft part sarcomas. HMB-45 demonstrated a strong diffuse cytoplasmic positive reaction with the smooth-muscle component in all cases of renal angiomyolipoma and in the one case of lymphangioleiomyomatosis. All alveolar soft part sarcomas, leiomyomas, and leiomyosarcomas were uniformly negatively stained by this antibody. We discuss the widening spectrum of lesions that are reactive with HMB-45 and the relationship of angiomyolipoma and lymphangioleiomyomatosis.
近期报告已阐明了可与HMB-45发生反应的多种组织类型。血管平滑肌脂肪瘤已证实呈持续阳性，但仅在平滑肌细胞中如此。在本报告中，我们检查了5例肾血管平滑肌脂肪瘤和20例具有相似形态特征且可能具有相似组织发生学的间叶性病变。这些病变包括1例腹膜后淋巴管平滑肌瘤病、5例上皮样平滑肌瘤、9例具有上皮样特征的平滑肌肉瘤以及5例肺泡软组织肉瘤。HMB-45在所有肾血管平滑肌脂肪瘤病例及1例淋巴管平滑肌瘤病病例中，均显示出与平滑肌成分强烈的弥漫性胞质阳性反应。所有肺泡软组织肉瘤、平滑肌瘤和平滑肌肉瘤均被该抗体均匀地染为阴性。我们讨论了与HMB-45发生反应的病变谱范围扩大的情况以及血管平滑肌脂肪瘤与淋巴管平滑肌瘤病的关系。
