Molnar-Nadasdy G, Haesly I, Reed J, Altshuler G
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City.
Arch Pathol Lab Med. 1994 Jul;118(7):757-9.
There are many pregnant mothers who have acquired immunodeficiency syndrome or who require immunosuppressive therapy for sundry reasons. Despite this, we have been able to find only one English-language report of placental cryptococcosis. We have had an opportunity to treat a pregnant mother who suffered from cryptococcal meningitis that complicated steroid treatment for lupus erythematosus. At 31 weeks' gestation, fetal distress necessitated delivery by cesarean section. The placenta had focally abundant intervillous and perivillous cryptococcal yeast cells, but there was no chorioamnionitis or villitis. Although there were no clinical or placental signs of transplacental infection, immunohistochemical labeling of villous stromal cells showed a conspicuously increased number of fetal macrophages.
有许多感染了获得性免疫缺陷综合征或因各种原因需要进行免疫抑制治疗的孕妇。尽管如此，我们仅能找到一篇关于胎盘隐球菌病的英文报道。我们有机会治疗一名患有隐球菌性脑膜炎的孕妇，该脑膜炎是狼疮性红斑类固醇治疗引发的并发症。妊娠31周时，胎儿窘迫需要剖宫产分娩。胎盘局部绒毛间隙和绒毛周围有大量隐球菌酵母细胞，但没有绒毛膜羊膜炎或绒毛炎。尽管没有经胎盘感染的临床或胎盘迹象，但对绒毛间质细胞进行免疫组化标记显示胎儿巨噬细胞数量明显增加。
