Yoshida M, Watanabe C, Satoh H, Kishimoto T, Yamamura Y
Department of Public Health, St. Marianna University School of Medicine, Kawasaki, Japan.
Arch Toxicol. 1994;68(3):174-8. doi: 10.1007/s002040050051.
Maternal guinea pigs were injected with mercuric chloride (HgCl2; 1 mg Hg/kg body weight) or methylmercury (MeHg; 1 mg Hg/kg) 12 h after parturition, and exposure of the offspring to mercury (Hg) via breast milk were studied on days 3, 5 and 10 postpartum. Milk Hg concentrations were lower than maternal plasma Hg concentrations regardless of the form of Hg given to the dams. Milk Hg was higher in HgCl2-treated dams than in MeHg-treated dams. In MeHg-treated dams, MeHg was separately determined. While the ratio of MeHg to T-Hg decreased in the dams' plasma, it did not in the milk. There was a strong correlation between milk and plasma T-Hg concentrations in HgCl2 treated dams. In the milk of MeHg-treated dams, the plasma MeHg concentrations correlated better than did the plasma T-Hg concentrations. In the offspring, regardless of the chemical forms of Hg given to the dams, the highest Hg concentrations were found in the kidney, followed by the liver and the brain. Brain Hg concentrations were, however, significantly higher in the offspring of MeHg-treated dams than in those of HgCl2-treated dams. In addition, Hg levels in the major organs of the offspring of HgCl2-treated dams peaked on day 5 postpartum, while those of MeHg-treated dams did not show a significant decrease up to day 10 postpartum. These facts indicate that the two chemical forms of Hg were transferred to the offspring via the breast milk and were distributed differently, depending on the chemical form, to the offspring's tissues.
产后12小时给母豚鼠注射氯化汞（HgCl₂；1毫克汞/千克体重）或甲基汞（MeHg；1毫克汞/千克），并在产后第3天、第5天和第10天研究后代通过母乳接触汞（Hg）的情况。无论给母鼠的汞形态如何，乳汁中的汞浓度均低于母鼠血浆中的汞浓度。HgCl₂处理组母鼠的乳汁汞含量高于MeHg处理组母鼠。在MeHg处理组母鼠中，对MeHg进行了单独测定。虽然母鼠血浆中MeHg与总汞（T-Hg）的比值下降，但乳汁中未下降。HgCl₂处理组母鼠的乳汁和血浆T-Hg浓度之间存在很强的相关性。在MeHg处理组母鼠的乳汁中，血浆MeHg浓度的相关性优于血浆T-Hg浓度。在后代中，无论给母鼠的汞化学形态如何，肾脏中的汞浓度最高，其次是肝脏和大脑。然而，MeHg处理组母鼠后代的大脑汞浓度显著高于HgCl₂处理组母鼠后代。此外，HgCl₂处理组母鼠后代主要器官中的汞水平在产后第5天达到峰值，而MeHg处理组母鼠后代的汞水平在产后第10天之前没有显著下降。这些事实表明，两种汞化学形态通过母乳转移到后代体内，并根据化学形态在后代组织中的分布有所不同。
