Alldredge B K, Knutsen A P, Ferriero D
Department of Clinical Pharmacy, University of California, San Francisco.
Pediatr Neurol. 1994 Mar;10(2):169-71. doi: 10.1016/0887-8994(94)90054-x.
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported. In 3 patients, the syndrome was exacerbated after conversion of therapy to another antiepileptic drug with an aromatic ring chemical structure. In vitro lymphocyte transformation studies confirmed cross-reactivity to one or more aromatic AEDs in 3 patients. In all patients, discontinuation of aromatic AEDs resulted in resolution of symptoms and in 3 patients who required continued AED therapy, valproic acid was well tolerated.
报告了4例在卡马西平治疗期间出现抗癫痫药物（AED）超敏综合征症状的患者。在3例患者中，将治疗转换为另一种具有芳香环化学结构的抗癫痫药物后，该综合征加重。体外淋巴细胞转化研究证实3例患者对一种或多种芳香族AED存在交叉反应性。在所有患者中，停用芳香族AED后症状得到缓解，在3例需要继续AED治疗的患者中，丙戊酸耐受性良好。
