Ikarashi F, Nakano Y, Okura T
Department of Otolaryngology, Niigata University School of Medicine, Japan.
Eur Arch Otorhinolaryngol. 1994;251(2):100-4. doi: 10.1007/BF00179901.
The relationship between the degree of chronic middle ear inflammation and pneumatization was investigated in the pig as an animal model, since its tympanic bulla closely resembles the human mastoid air cell system. Ten piglets (sire: Landrace-Hampshire crossbreed; dam: Duroc) were used for this experiment. Four ears of two animals served as the normal control group and 16 ears of eight animals were the experimental group. In this latter group, otitis media was induced by injecting glycerin into the middle ear clefts 1 months after birth, and the degree of inflammation was varied by administering or withholding antibiotics (cefamandole and dibekacin) and adjusting the dosage regimen. The animals were sacrificed 6 months after birth and examined for the relationship between the degree of chronic middle ear inflammation present and tympanic bulla pneumatization. Various degrees of inflammation were successfully induced by injecting the antibiotics: the more severe the inflammation found, the greater was the inhibition of pneumatization. Findings demonstrated that the degree of inhibition of pneumatization produced was directly proportional to the severity of chronic middle ear inflammation.
由于猪的鼓泡与人类乳突气房系统极为相似，因此以猪作为动物模型，研究慢性中耳炎症程度与气化之间的关系。本实验选用了10头仔猪（父本：长白-汉普夏杂交种；母本：杜洛克）。两只动物的4只耳朵作为正常对照组，8只动物的16只耳朵作为实验组。在实验组中，出生1个月后通过向中耳裂隙注射甘油诱发中耳炎，并通过给予或停用抗生素（头孢孟多和双去甲万古霉素）以及调整给药方案来改变炎症程度。出生6个月后处死动物，检查存在的慢性中耳炎症程度与鼓泡气化之间的关系。通过注射抗生素成功诱发了不同程度的炎症：炎症越严重，气化抑制作用越强。研究结果表明，产生的气化抑制程度与慢性中耳炎症的严重程度直接相关。
