Shuai K
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
Curr Opin Cell Biol. 1994 Apr;6(2):253-9. doi: 10.1016/0955-0674(94)90144-9.
Recent studies on gene activation by interferons have uncovered a direct signaling pathway from the cell-surface receptor for interferons to the nucleus. Activation of JAK tyrosine kinases by interferons leads to activation, by direct tyrosine phosphorylation, of a family of latent cytoplasmic transcription factors named STATs (for signal transducers and activators of transcription), which then translocate to the nucleus to direct transcriptional activation.
近期关于干扰素激活基因的研究揭示了一条从干扰素细胞表面受体到细胞核的直接信号通路。干扰素激活JAK酪氨酸激酶，导致一类名为STATs（信号转导和转录激活因子）的潜在细胞质转录因子通过直接酪氨酸磷酸化而被激活，这些转录因子随后转移至细胞核以指导转录激活。
