Bollen A M, Eyre D R
Department of Orthodontics, University of Washington, Seattle 98195.
Bone. 1994 Jan-Feb;15(1):31-4. doi: 10.1016/8756-3282(94)90888-5.
When bone is resorbed, cross-linking amino acids from collagen type I (pyridinolines) are excreted in the urine as small peptides. The purpose of this cross-sectional study was to measure the urinary excretion of type I collagen bone degradation products in children and to correlate the results with growth velocity on a population basis. Spot urines from 1076 children and 24 adults were analyzed. The concentrations of cross-linked N-telopeptides of collage type I were measured using a new monoclonal antibody-based microtiter-plate assay, and normalized to creatinine. Age-related changes in cross-link excretion mirrored published standard growth velocity rates for males and females. The correlation coefficient between growth rates and cross-link excretion was 0.91. These results encourage more definitive longitudinal studies where growth rates and collagen cross-link excretion are correlated on an individual-patient basis.
当骨骼被吸收时，来自I型胶原蛋白的交联氨基酸（吡啶啉）会以小肽的形式随尿液排出。这项横断面研究的目的是测量儿童尿液中I型胶原蛋白骨降解产物的排泄量，并在群体基础上将结果与生长速度相关联。对1076名儿童和24名成年人的随机尿样进行了分析。使用基于新型单克隆抗体的微量滴定板分析法测量I型胶原蛋白交联N-端肽的浓度，并将其标准化为肌酐。交联排泄的年龄相关变化反映了已公布的男性和女性标准生长速度。生长速度与交联排泄之间的相关系数为0.91。这些结果鼓励进行更具确定性的纵向研究，在个体患者基础上关联生长速度和胶原蛋白交联排泄情况。
