γ-氨基丁酸B受体介导的脊髓抑制作用。
GABA-B receptor-mediated spinal inhibition.
作者信息
Curtis D R, Lacey G
机构信息
Division of Neuroscience, John Curtin School of Medical Research, Canberra, Australia.
出版信息
Neuroreport. 1994 Jan 31;5(5):540-2. doi: 10.1097/00001756-199401000-00002.
The intravenous administration to pentobarbitone-anaesthetized cats of the GABA-B antagonists CGP 46381 and CGP 35348 blocks the longer duration component of the inhibition of lumbar extensor monosynaptic reflexes by tetanic stimulation of low threshold flexor primary afferent fibres. GABA-B receptors thus appear to be associated with this inhibitory process, in addition to bicuculline-sensitive GABA-A receptors associated with shorter duration 'presynaptic' inhibition of reflexes and the depolarization of the terminals of primary afferent fibres.
给戊巴比妥麻醉的猫静脉注射GABA - B拮抗剂CGP 46381和CGP 35348，可阻断由低阈值屈肌初级传入纤维的强直刺激对腰伸肌单突触反射抑制的较长持续时间成分。因此，除了与反射的较短持续时间“突触前”抑制以及初级传入纤维终末去极化相关的荷包牡丹碱敏感的GABA - A受体外，GABA - B受体似乎也与这一抑制过程有关。
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