Rasheed Q, Cacchione J G, Berry J, Richards F, Bryant L, Strony J, Enger C, Hodgson J M
Division of Cardiology, University Hospitals of Cleveland, OH 44106.
Cathet Cardiovasc Diagn. 1994 Mar;31(3):240-5. doi: 10.1002/ccd.1810310317.
Local intramural delivery of various pharmacologic agents following angioplasty has been proposed as a means of reducing restenosis. This study tested whether local intramural delivery of aqueous solutions using an infusion balloon could be accomplished safely in normal vessels and whether such infusion was safe following standard angioplasty in diseased vessels. Infusion of aqueous agents into normal canine arteries had no adverse effect. Infusion of several aqueous agents (< or = 4 cc at 4 atm) into diseased swine iliac arteries following balloon angioplasty did not worsen existing or create new dissections. Histologically, infusion treated vessels did not differ in either model from vessels treated with angioplasty alone. We conclude that local intramural drug infusion does not create new, or worsen existing, dissections produced during standard balloon angioplasty in diseased vessels.
血管成形术后在局部血管壁内递送各种药理剂已被提议作为减少再狭窄的一种方法。本研究测试了使用输注球囊在正常血管中安全地完成局部血管壁内递送水溶液是否可行，以及在病变血管中进行标准血管成形术后进行这种输注是否安全。向正常犬动脉中输注水剂没有不良影响。在球囊血管成形术后向病变的猪髂动脉中输注几种水剂（4个大气压下≤4毫升）不会使现有的夹层恶化或产生新的夹层。从组织学上看，在两种模型中，输注治疗的血管与仅接受血管成形术治疗的血管没有差异。我们得出结论，在病变血管中进行标准球囊血管成形术期间，局部血管壁内药物输注不会产生新的夹层，也不会使现有的夹层恶化。
