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[与巨细胞病毒感染相关的比克斯特法夫脑干脑炎]

[Bickerstaff's brainstem encephalitis associated with cytomegalovirus infection].

作者信息

Kanzaki A, Yabuki S, Yuki N

机构信息

Department of Neurology, Kochi Municipal Central Hospital.

出版信息

Rinsho Shinkeigaku. 1994 Apr;34(4):399-401.

PMID:8026140
Abstract

A 17-year-old girl was admitted to our hospital because of drowsiness, diplopia and gait difficulty. She had been well until ten days before admission when fever, drowsiness, headache and general fatigue developed. On admission, there were drowsiness, ophthalmoplegia, ataxia and hyporeflexia. CSF cells and anti-CMV antibody titers increased. CMV-DNA was detected in the CSF by the polymerase chain reaction (PCR). Serum anti-GQ1b antibody was positive. During recovery, forced laughing temporarily appeared. The neurological symptoms disappeared completely. CSF anti-CMV antibody titers became normalized and CSF CMV-DNA-PCR became negative. This is the first case report of Bickerstaff's brainstem encephalitis associated with CMV infection.

摘要

一名17岁女孩因嗜睡、复视和步态困难入院。入院前十天她一直状况良好,之后出现发热、嗜睡、头痛和全身乏力。入院时,存在嗜睡、眼肌麻痹、共济失调和反射减退。脑脊液细胞和抗巨细胞病毒抗体滴度升高。通过聚合酶链反应(PCR)在脑脊液中检测到巨细胞病毒DNA。血清抗GQ1b抗体呈阳性。恢复过程中,曾短暂出现强制性哭笑。神经症状完全消失。脑脊液抗巨细胞病毒抗体滴度恢复正常,脑脊液巨细胞病毒DNA-PCR检测转为阴性。这是首例与巨细胞病毒感染相关的比克斯特法夫脑干脑炎病例报告。

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