非胰岛素依赖型糖尿病合并蛋白尿患者尿中内皮素-1样免疫反应性排泄增加。
Increased urinary endothelin-1-like immunoreactivity excretion in NIDDM patients with albuminuria.
作者信息
Lee Y J, Shin S J, Tsai J H
机构信息
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
出版信息
Diabetes Care. 1994 Apr;17(4):263-6. doi: 10.2337/diacare.17.4.263.
OBJECTIVE
To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria.
RESEARCH DESIGN AND METHODS
Urinary ET-1-LI substance was determined by radioimmunoassay in 45 normoalbuminuric and 28 albuminuric NIDDM patients.
RESULTS
The mean amounts of 24-h ET-1-LI excretion in NIDDM patients with normoalbuminuria and albuminuria were 154.9 +/- 13.5 and 174.4 +/- 12.9 ng/day, respectively. The latter was significantly higher than that of the 40 normal control subjects (111.8 +/- 7.9 ng/day, P < 0.01).
CONCLUSIONS
The increase in urinary ET-1-LI substance excretion in patients with albuminuria suggests that ET-1 may be a pathogenetic factor in diabetic nephropathy.
目的
测定非胰岛素依赖型糖尿病（NIDDM）患者尿中内皮素-1样免疫反应性物质（ET-1-LI），并研究蛋白尿患者尿ET-1-LI排泄是否升高。
研究设计与方法
采用放射免疫分析法测定45例正常白蛋白尿和28例白蛋白尿NIDDM患者尿中ET-1-LI物质。
结果
正常白蛋白尿和白蛋白尿NIDDM患者24小时ET-1-LI排泄量的均值分别为154.9±13.5和174.4±12.9 ng/天。后者显著高于40例正常对照者（111.8±7.9 ng/天，P<0.01）。
结论
白蛋白尿患者尿ET-1-LI物质排泄增加提示ET-1可能是糖尿病肾病的致病因素。
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